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4,5 The FDA approval of Wegovy was based on the results of the STEP ( S emaglutide Tr eatment E ffect in P eople with Obesity) clinical trial program, which included four phase 3a clinical trials involving approximately 4,500 patients

The incidences of major depressive disorder, anxiety, and suicidal ideations or attempts, as well as their hazard ratios, are higher in the GLP-1 RA group, indicating an association with GLP-1 RA treatment over time

These are the earliest and most reliable indicators of GLP-1 and GIP receptor activation

In general, cognitive focus and sexual health may improve within days and weeks while other results (muscle growth for example) may take weeks to months